MEdPACTO

Papers

• GX-I7, a long-acting IL-7, safely and effectively increased peripheral CD8+/CD4+ T cells and TILs in patients with locally advanced or metastatic solid tumours.
  Br J Cancer. 2025 Jun 9. doi: 10.1038/s41416-025-03069-3. Online ahead of print.PMID: 40490502
• GX-188E DNA vaccine plus pembrolizumab in HPV 16- and/or 18-positive recurrent or advance cervical cancer: a phase 2 trial.
  E ClinicalMedicine. 2024 Jul 13;74:102716. doi: 10.1016/j.eclinm.2024.102716. eCollection 2024 Aug.PMID: 39823099
• Safety and immunogenicity of two recombinant DNA COVID-19 vaccines containing the coding regions of the spike or spike and nucleocapsid proteins: an interim analysis of two open-label, non-randomised, phase 1 trials in healthy adults.
  Lancet Microbe. 2022 Mar;3(3):e173-e183. doi: 10.1016/S2666-5247(21)00358-X. Epub 2022 Feb 8.PMID: 3515606
• Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial.
  Lancet Oncol. 2020 Dec;21(12):1653-1660. doi: 10.1016/S1470-2045(20)30486-1.PMID: 33271094
• A glycosylated Fc-fused glucagon-like peptide-1 receptor agonist exhibits equivalent glucose lowering to but fewer gastrointestinal side effects than dulaglutide.
  Diabetes Obes Metab. 2020 Aug;22(8):1455-1468. doi: 10.1111/dom.14058. Epub 2020 Jun 3.PMID: 32314505
• A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3.
  Clin Cancer Res. 2020 Apr 1;26(7):1616-1623. doi: 10.1158/1078-0432.CCR-19-1513. Epub 2019 Nov 14.PMID: 31727676
• Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB.
  PLoS One. 2015 Nov 6;10(11):e0138201. doi: 10.1371/journal.pone.0138201. eCollection 2015.PMID: 26544846
• Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients.
  Nat Commun. 2014 Oct 30;5:5317. doi: 10.1038/ncomms6317.PMID: 25354725
• Red ginseng extract ameliorates autoimmune arthritis via regulation of STAT3 pathway, Th17/Treg balance, and osteoclastogenesis in mice and human.
  Mediators Inflamm. 2014;2014:351856. doi: 10.1155/2014/351856. Epub 2014 Jul 23.PMID: 25147435
• Halofuginone ameliorates autoimmune arthritis in mice by regulating the balance between Th17 and Treg cells and inhibiting osteoclastogenesis.
  Arthritis Rheumatol. 2014 May;66(5):1195-207. doi: 10.1002/art.38313.PMID: 2478218
• MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis.
  Exp Mol Med. 2013 Apr 26;45(4):e20. doi: 10.1038/emm.2013.39.PMID: 23619188

Dr. John Letterio is an interim Director of UH Seidman Cancer Center at Cleveland Medical Center and a Division Chief at the Cancer Research Center at UH Rainbow Babies and Children’s Hospital, Case Western Reserve University (UH BR&C).

He has been researching TGF-β agonists in immune disorder for a long time with CEO SeongJin Kim, CEO of MedPacto.

Dr. John Letterio was the first to map out and develop bi-dentate inhibitor of Cdk5 and also had defined CDK5 roles as Modulators of tumor therapeutics and immune checkpoint regulatory molecules.

Dr. Isaac Kim is currently serving as a Professor Urology and the head of the department at Yale University School of Medicine.

He has extensive clinical experience in urological oncology including androgen signaling of prostate cancer in the tumor microenvironment, Dr. Kim is currently practicing a clinical trial for bone metastasis of urinary cancer.

Dr. Hyun Bae, MD is a distinguished spine fellowship and trained board-certified orthopedic surgeon practicing at Spine-center at Cedars-Sinai Medical Center and the Spine Institute in Santa Monica CA.

His specialties lie in the repair of In Vitro Diagnostics (IVD) and evaluating instrumentation for spinal fusion and grafting materials. Dr. Bae has written or co-authored more than 70 published scientific papers and has around 30 patents.

Dr. Greg Licholai, MD is the Chief Medical & Innovation Officer at ICON plc., Co-Director of Digital Health Center, and Professor at Yale School of Management, teaches Healthcare Innovation at Harvard Business School.

He had previously served as the President of rare diseases at Moderna Therapeutics, President and Chief Medical Officer at Castle Creek Pharmaceuticals and partner at McKinsey & Co. where he ran the healthcare data service line.